Clinical Trials

You can search for pending or recruiting clinical trials through the National Library of Medicine’s clinical trials website, clinicaltrials.gov.

This site also maintains a list of recruiting studies. If you are a principal investigator or study site and wish to add an IRB-approved trial to our listings, or if you wish to have your study information amended or removed from ntminfo.org, please email ntmmail@ntminfo.org.

National Library of Medicine Clinical Trials Listings

Search for pending or recruiting clinical trials on clinicaltrials.gov

ARISE/ENCORE Clinical Trial Program for MAC Lung Disease

This is a frontline clinical trial program of ARIKAYCE^® (amikacin liposome inhalation suspension) in patients with nontuberculous mycobacterial (NTM) lung disease caused by Mycobacterium avium complex (MAC), consisting of ARISE, an interventional study designed to validate cross-sectional and longitudinal characteristics of patient-reported outcome (PRO) tools in MAC lung disease, and ENCORE, a pivotal trial designed to establish, using the PRO tools validated in the ARISE trial, the clinical benefits and evaluate the safety of ARIKAYCE in patients with newly diagnosed MAC lung disease. For more information, click here to visit the ARISE/ENCORE study page.

CleaR-Mac – RHB-204 for the Treatment of Pulmonary Mycobacterium Avium Complex Disease (CleaR-MAC)

A 2-part multi-center, Phase 3, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of RHB-204 in adult subjects with underlying nodular bronchiectasis and documented MAC lung infection. Learn More.

Evaluation of the Lung Microbiome in NTM Bronchiectasis

A biomarker cohort study design is proposed to study whether specific airway microbiota alterations are associated with pulmonary Non-tuberculous mycobacteria (NTM) disease. Learn more.

Study of Mycobacterial Infections

This study will examine the symptoms, course of disease and treatment of non-tuberculous mycobacterial (NTM) infections, as well as the genetics involved in these infections. Learn more.

Clofazimine in the Treatment of Pulmonary Nontuberculous Mycobacterium Avium Complex (MAC)

Investigators have developed a randomized, placebo-controlled clinical trial to assess the clinical efficacy and safety of clofazimine when used to treat MAC lung disease. Learn more.

PRospective Evaluation of NTM Disease In CysTic Fibrosis (PREDICT)

The PREDICT study will help standardize the diagnosis and collect relevant data associated with the diagnosis of NTM disease in CF patients to build a framework for future therapeutic trials. Learn more.

Prospective Algorithm for Treatment of NTM In Cystic Fibrosis (PATIENCE)

The PATIENCE study will help standardize the diagnosis and collect relevant data associated with the treatment of NTM disease in CF patients to build a framework for future therapeutic trials. Learn more.