Clinical Trials

You can search for pending or recruiting clinical trials through the National Library of Medicine’s clinical trials website, clinicaltrials.gov.

This site also maintains a list of recruiting studies. If you are a principal investigator or study site and wish to add an IRB-approved trial to our listings, or if you wish to have your study information amended or removed from ntminfo.org, please email ntmmail@ntminfo.org.

Recruiting patients with NTM MAC lung disease to participate in a research study

Now recruiting participants for an interview and questionnaire-only research study of
NTM MAC lung disease
We are currently recruiting patients with NTM MAC lung disease to participate in a research
study being conducted by Evidera, a research organization, with funding from AN2
Therapeutics, a biopharmaceutical company.

Study Goals: The goal of this interview study is to better understand the symptoms and
impacts of MAC lung disease to help Evidera pick or create questionnaires to be used in
treatment studies of this disease.

  • Study Activities: If you qualify and choose to participate, you will be asked to do the following:
    Have your medical team complete a brief form that confirms you meet study
    requirements
  • Sign an electronic consent form and complete a few questionnaires about your health
    and your demographics (age, sex, race, etc.)
  • Participate in a telephone interview lasting about 60 minutes with a researcher from
    Evidera. During the interview, you will be asked to describe the symptoms and impacts
    you experience as a result of MAC lung disease.
    You will not receive any treatment as part as this study. You will receive $200 if you complete
    all of the above activities.

To Learn More: If you are interested in learning more, please contact Evidera at
NTMlungstudy@ppd.com or toll-free at 877-888-3232.

National Library of Medicine Clinical Trials Listings

Search for pending or recruiting clinical trials on clinicaltrials.gov

CleaR-Mac – RHB-204 for the Treatment of Pulmonary Mycobacterium Avium Complex Disease

A 2-part multi-center, Phase 3, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of RHB-204 in adult subjects with underlying nodular bronchiectasis and documented MAC lung infection. Learn More.

ARISE/ENCORE Clinical Trial Program for MAC Lung Disease

This is a frontline clinical trial program of ARIKAYCE® (amikacin liposome inhalation suspension) in patients with nontuberculous mycobacterial (NTM) lung disease caused by Mycobacterium avium complex (MAC), consisting of ARISE, an interventional study designed to validate cross-sectional and longitudinal characteristics of patient-reported outcome (PRO) tools in MAC lung disease, and ENCORE, a pivotal trial designed to establish, using the PRO tools validated in the ARISE trial, the clinical benefits and evaluate the safety of ARIKAYCE in patients with newly diagnosed MAC lung disease. For more information, click here to visit the ARISE/ENCORE study page.

Evaluation of the Lung Microbiome in NTM Bronchiectasis

A biomarker cohort study design is proposed to study whether specific airway microbiota alterations are associated with pulmonary Non-tuberculous mycobacteria (NTM) disease. Learn more.

Study of Mycobacterial Infections

This study will examine the symptoms, course of disease and treatment of non-tuberculous mycobacterial (NTM) infections, as well as the genetics involved in these infections. Learn more.

Clofazimine in the Treatment of Pulmonary Nontuberculous Mycobacterium Avium Complex (MAC)

Investigators have developed a randomized, placebo-controlled clinical trial to assess the clinical efficacy and safety of clofazimine when used to treat MAC lung disease. Learn more.

PRospective Evaluation of NTM Disease In CysTic Fibrosis (PREDICT)

The PREDICT study will help standardize the diagnosis and collect relevant data associated with the diagnosis of NTM disease in CF patients to build a framework for future therapeutic trials. Learn more.

Prospective Algorithm for Treatment of NTM In Cystic Fibrosis (PATIENCE)

The PATIENCE study will help standardize the diagnosis and collect relevant data associated with the treatment of NTM disease in CF patients to build a framework for future therapeutic trials. Learn more.

National Library of Medicine Clinical Trials Listings

Search for pending or recruiting clinical trials on clinicaltrials.gov

CleaR-Mac – RHB-204 for the Treatment of Pulmonary Mycobacterium Avium Complex Disease

A 2-part multi-center, Phase 3, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of RHB-204 in adult subjects with underlying nodular bronchiectasis and documented MAC lung infection. Learn More.

ARISE/ENCORE Clinical Trial Program for MAC Lung Disease

This is a frontline clinical trial program of ARIKAYCE® (amikacin liposome inhalation suspension) in patients with nontuberculous mycobacterial (NTM) lung disease caused by Mycobacterium avium complex (MAC), consisting of ARISE, an interventional study designed to validate cross-sectional and longitudinal characteristics of patient-reported outcome (PRO) tools in MAC lung disease, and ENCORE, a pivotal trial designed to establish, using the PRO tools validated in the ARISE trial, the clinical benefits and evaluate the safety of ARIKAYCE in patients with newly diagnosed MAC lung disease. For more information, click here to visit the ARISE/ENCORE study page.

Evaluation of the Lung Microbiome in NTM Bronchiectasis

A biomarker cohort study design is proposed to study whether specific airway microbiota alterations are associated with pulmonary Non-tuberculous mycobacteria (NTM) disease. Learn more.

Study of Mycobacterial Infections

This study will examine the symptoms, course of disease and treatment of non-tuberculous mycobacterial (NTM) infections, as well as the genetics involved in these infections. Learn more.

Clofazimine in the Treatment of Pulmonary Nontuberculous Mycobacterium Avium Complex (MAC)

Investigators have developed a randomized, placebo-controlled clinical trial to assess the clinical efficacy and safety of clofazimine when used to treat MAC lung disease. Learn more.

PRospective Evaluation of NTM Disease In CysTic Fibrosis (PREDICT)

The PREDICT study will help standardize the diagnosis and collect relevant data associated with the diagnosis of NTM disease in CF patients to build a framework for future therapeutic trials. Learn more.

Prospective Algorithm for Treatment of NTM In Cystic Fibrosis (PATIENCE)

The PATIENCE study will help standardize the diagnosis and collect relevant data associated with the treatment of NTM disease in CF patients to build a framework for future therapeutic trials. Learn more.

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