It seems like in the beginning, over twenty years ago, my sister was on cipro every now and then and that was the only med she took. In the last 8 years she has been on many meds of which she has had a hard time tolerating most of them. It does seem that the more drugs she takes, the more things happen to her lungs. I don’t understand this disease at all. I know you have to be on antibiotics to fight the infections so my feeling is to keep on with the meds that your doctor prescribes. My sister has loss her hearing due to the Amikacin and she gets very frustrated with that and we keep hoping that some of her hearing comes back.