I was on the Big Three for 3 months. It was a complicated schedule–each pill 3 times a week but not all on the same 3 days. One med was twice a day 3 times a week; the other 2 were once a day on alternate days. I always had Sundays “off”. I was so sick the entire time that I spent the last month I was on them totally in bed, barely eating, and only getting up to use the bathroom. I finally just quit! I felt better almost immediately and had nearly 2 months of feeling pretty good. Then all the MAC symptoms returned in spades. So–here I sit in Denver waiting to check into National Jewish on Monday for two weeks. I don’t know how this will turn out but I do know taking those drugs on any kind of schedule is not for me.