SPR720

The purpose of this clinical trial is to evaluate SPR720 in a double-blind, placebo-controlled study in healthy subjects consisting of single ascending dose and multiple ascending dose cohorts. SPR720 is an orally administered antimicrobial agent being developed for the treatment of nontuberculous mycobacterial (NTM) infections.

The advancement of SPR720 into the Phase 1 clinical assessment was based on SPR720’s favorable profile exhibited in a suite of pre-clinical in vitro and in vivo safety, toxicology and ADME (absorption, distribution, metabolism and excretion) studies, as well as its demonstration of potent in vitro and in vivo activity versus multiple, clinically important species of NTM, including Mycobacterium avium complex and Mycobacterium abscessus. The collective pre-clinical data to date suggest that SPR720 has an acceptable safety profile, encouraging target pathogen efficacy, drug distribution to key sites of infection, such as the lung, and a wide therapeutic margin.

Learn more about SPR720.

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